nueva clasificacion de los tumores renales

Monday, 17 August 2009
RIO DE JANEIRO, BRAZIL (UroToday.com) - Clear cell carcinoma occurs in 60% of resected adult tumors. They are yellow tumors with nests of clear cytoplasm and express many growth factors including VEGF, EGFR and Carbonic anhydrase. VHL gene mutations are present.
Papillary cancers comprise 15% of resected adult tumors. Type I has very good survival and type II poor survival. It is unclear if they are really distinct entities molecularly.
Chromophobe renal tumors comprise 5% of adult renal tumors and they have a greater than 90% 10-year survival. While they can have very aggressive sarcomatoid variants, it is rare. They are generally unifocal tumors with large cells that can be confused with oncocytomas due to large amount of pink cytoplasm.
Collecting duct tumors are seen in less than 1% of all renal tumors. They occur in young patients and are very aggressive. They are infiltrative versus circumscribed and virtually indistinguishable from urothelial cancer or renal pelvic tumors. Medullary tumors occur only in patients with sickle cell trait and are uniformly lethal within 6 months.
Finally, mucinous tubular and spindle cell tumors are new entities in the classification system. They are low grade and occur predominately in women.
Presented by David Grignon, MD at the VI Maratona Urológica do Rio de Janeiro - August 14 - 15, 2009.