rol de de las immunophilinas en la recuperacion de la funcion erectil luego de la injuria del nervio cavernoso

1: J Sex Med. 2009 Mar;6 Suppl 3:340-6. Links

Role of immunophilins in recovery of erectile function after cavernous nerve injury.

Sezen SF, Lagoda G, Burnett AL.

James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Department of Urology, Baltimore, MD 21287, USA. ssezen1@jhmi.edu

INTRODUCTION: Immunophilin ligands provide potentially new alternatives for the treatment of erectile dysfunction (ED), which occurs after injury of the cavernous nerves (CNs). AIM: To review and update current knowledge of the neurotrophic effects and likely mechanism of action of immunophilin proteins with emphasis on the FK506-binding protein (FKBP) subfamily and the role of immunophilin ligands for the treatment of CN injury-induced ED. METHODS: Review of available reports of studies investigating the effects and neurotrophic mechanisms of immunophilin ligands involved in erectile function recovery in rodent models of CN injury. MAIN OUTCOME MEASURES: Erection parameters and molecular correlations associated with CN injury and functional recovery. RESULTS: Treatment with prototype immunosuppressive immunophilin ligands FK506 (FK) and rapamycin (Rapa) improve erectile function in animal models of CN injury. Similarly, non-immunosuppressive analogs such as GPI-1046 and FK1706 are effective in recovery of erections after CN injury. Neuronal nitric oxide may influence the erection recovery effects of immunophilin ligands after CN injury. FKBPs 38 and 65 expression changes in the penis and its innervation coincide with the neurotrophic effects of immunophilin ligands. Antioxidative actions of immunophilin ligands contribute to their neurotrophic effects. Immunophilins are localized to nerves coursing in human prostate and penile tissue. CONCLUSIONS: The findings support the hypothesis that immunophilin ligands, working through specific receptor mechanisms that are specific to injured CN, are potentially useful to sustain erectile function in men following radical prostatectomy.

PMID: 19267858 [PubMed - indexed for MEDLINE]

aspectos sicosociales de la recuperacion sexual luego del tratamiento del Cáncer de próstata

1: Int J Impot Res. 2009 Mar-Apr;21(2):99-106. Epub 2009 Jan 22. Links

The psychosocial aspects of sexual recovery after prostate cancer treatment.

Wittmann D, Northouse L, Foley S, Gilbert S, Wood DP Jr, Balon R, Montie JE.

Department of Urology, University of Michigan, Ann Arbor, MI 48109-5330, USA. dwittman@med.umich.edu

Prostate cancer affects one in six American men. Erectile and sexual dysfunctions are long-term side effects of prostate cancer treatment. PubMed database was searched for papers on prostate cancer-related sexual recovery for men and couples. The search yielded articles on (1) the treatment of erectile dysfunction, (2) men's psychological and culturally diverse adaptation to the sexual side effects; (3) the impact of prostate cancer on couples' relationships; and (4) interventions to promote sexual function. Erectile dysfunction after prostate cancer treatment has been widely studied. Research on the sexual recovery of men and couples or understanding it in a cultural context is scarce. Greater focus on the impact of sexual sequelae of prostate cancer treatment on men as well as couples in diverse groups is needed. Clinical implications for treating sexual dysfunction and promoting sexual recovery for prostate cancer survivors and their partners are discussed. Recommendations for future research are provided.

PMID: 19158798 [PubMed - indexed for MEDLINE